Much research has already been carried out into various cancers and both cannabinoids as well as the ketogenic diet…
Cannabinoids
| The heterogeneity and complexity of Cannabis extracts as antitumor agents – Baram, Peled, Berman, Yellin, Besser, Benami, Louria-Hayon, Lewitus & Meiri (2019) – Oncotarget |
| The Potential for Pharmacokinetic Interactions Between Cannabis Products and Conventional Medications – Qian, Gurley & Markowitz (2019) – Journal of Clinical Psychopharmacology |
| Repositioning Cannabinoids in Recent Drug Discovery and it’s Manifestation in Cancer Therapy – Kulkarni & Goswami (2019) – EC Pharmacology and Toxicology |
| Nannocannabinoids for brain tumor drug delivery – Blanco, Romero & Torres-Suarez (2019) – Anales de la Real Academia Nacional de Farmacia |
| Cannabinoid Signaling in Cancer – Das, Kaul, Mishra, Charan & Ganju (2019) – Recent Advances in Cannabinoid Physiology and Pathology |
| What are the perspectives of cannabidiol (CBD) for the treatment of glioblastoma – Nahler (2018) – Clinical Sciences Research and Reports |
| Synthetic Cannabinoid Activity Against Colorectal Cancer Cells – Raup-Konsavage, Johnson, Legare, Yochum, Morgan & Vrana (2018) – Cannabis and Cannabinoid Research |
| Synergistic Effect of Cannabidiol with Conventional Chemotherapy Treatment – Strong, Rauvolfova, Jackson, Pham & Bryant (2018) – Blood |
| Analysis of Potential Anti-Cancer Effects of Cannabinol and Cannabidiol using HCC1806 and HEK293 Cell Lines – Galatonov, Li, Zhong & Kovalchuk (2018) – URSCA Proceedings |
| The current state and future perspectives of cannabinoids in cancer biology – Sledzinski, Zeyland, Slomski, Nowak (2018) – Cancer Medcine |
| Chronic Adolescent Δ 9 -Tetrahydrocannabinol Treatment of Male Mice Leads to Long-Term Cognitive and Behavioral Dysfunction, Which Are Prevented by Concurrent Cannabidiol Treatment – Murphy, Mills, Winstone & Mackie (2017) – Cannabis and Cannabinoid Research |
| Cannabidiol: State of the art and new challenges for therapeutic applications – Pisanti, Malfitano, Ciaglia, Lamberti, Ranieri, Cuomo, Abate, Figgiana, Proto, Fiore, Laezza & Bifulco (2017) – Pharmacology & Theraputics |
| The Pharmacology and Therapeutic Potential of Plant Cannabinoids – Cascio, Pertwee & Marini (2017) – Botany and Biotechnology |
| Quantitative Analyses of Synergistic Responses between Cannabidiol and DNA-Damaging Agents on the Proliferation and Viability of Glioblastoma and Neural Progenitor Cells in Culture – Deng, Ng, Ozawa & Stella (2017) – Journal of Pharmacology and Experimental Theraputics |
| Phytochemical Aspects and Therapeutic Perspective of Cannabinoids in Cancer Treatment – Vladimir‐Knežević, Blažeković, Štefan & Kindl (2017) – Intech |
| A Review of the Therapeutic Antitumor Potential of Cannabinoids – Bogdanovic, Mrdanovic & Borisev (2017) – The Journal of Alternative and Complimentary Medcine |
| From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology – Ligresti, De Petrocellis & Di Marzo (2016) – Physiological Reviews |
| Novel role of cannabinoid receptor 2 in inhibiting EGF/EGFR and IGF-I/IGF-IR pathways in breast cancer – Elbaz, Ahirwar, Ravi, Nasser & Ganju (2016) – Oncotarget |
| In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma – Fisher, Golan, Schib, PriChen, Smoum, Moshe, Peshes-Yaloz, Castiel, Waldman, Gallily, Mechoulam & Toren (2016) – Current Oncology |
| Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration – Nabissi, Morelli, Offidani & Santoni (2016) – Oncotarget |
| Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells – Lukhele & Motadi (2016) – BMC Complimentary and Alternative Medicine |
| Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: novel anti-tumor mechanisms of Cannabidiol in breast cancer – Elbaz, Nasser, Ravi, Wani, Ahirwar, Zhao, Oghumu, Satoskar, Shilo, Carson & Ganju (2015) – Molecular Oncology |
| Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells – Scott, Dennis, Dalgleish & Liu (2015) – Anticancer Research |
| Cannabidiol stimulates Aml-1a-dependent glial differentiation and inhibits glioma stem-like cells proliferation by inducing autophagy in a TRPV2-dependent manner – Nabissi, Morelli, Amantini, Liberati, Santoni, Ricci-Vitiani, Pallini & Santoni (2015) – iInternational Journal of Cancer |
| The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. A role for transient receptor potential vanilloid type-2 – Morelli, Offidani, Alesiani, Discepoli, Liberati, Olivieri, Santoni, Santoni, Leoni & Nabissi (2014) – International Journal of Cancer |
| The combination of cannabidiol and Delta9-tetrahydrocannabinol enhances the anticancer effects of radiation in an orthotopic murine glioma model – Scott, Dalgleish & Liu (2014) – Molecular Cancer Theraputics |
| Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer – Murase, Kawamura, Singer, Pakdel, Sarma, Judkins, Elwakeel, Dayal, Martinez-Martinez, Amere, Gujjar, Mahadevan, Desprez & McAllister (2014) – British Journal of Pharmacology |
| Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol – Romano, Borrelli, Pagano, Cascio, Pertwee & Izzo (2014) – Phytomedicine |
| Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1 – Haustein, Ramer, Linnebacher, Manda & Hinz (2014) – Biochamical Pharmacology |
| Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents – Nabissi, Morelli, Santoni & Santoni (2013) – Carcinogenesis |
| Critical appraisal of the potential use of cannabinoids in cancer management – Cridge& Rosengren (2013) – Cancer Management & Research |
| Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas – Rocha, Guilherme, Stefano & Silveira (2013) – Journal of Neuro-Oncology |
| Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme – Hernan Perez, Lorente, Gil-Alegre, Torres, Garcia-Taboada, Aberturas, Molpeceres, Velasco & Torres-Suarez (2013) – PLOS One |
| COX-2 and PPAR-gamma confer cannabidiol-induced apoptosis of human lung cancer cells – Ramer, Heinmann, Merkord, Rohde, Salamon, Linnenbacher & Hinz (2013) – Molecuar Cacer Theraputics |
| Cannabidiol, a Non-Psychoactive Cannabinoid Compound, Inhibits Proliferation and Invasion in U87MG and T98G Glioma Cells through a Multitarget Effect – Solinas, Massi, Cinquina, Bolognini, Gariboldi, Monti, Rubino & Parolaro (2013) – PLOS One |
| Cannabidiol inhibits angiogenesis by multiple mechanisms – Solinas, Massi, Cantelmo, Cattaneo, Cammarota, Bartolini, Cinquina, Valenti, Vicentini, Noonan, Albini & Parolaro (2012) – British Journal of Pharmacology |
| Towards the use of cannabinoids as antitumour agents – Velasco, Sanchez & Guzman (2012) – Nature Review Cancer |
| Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer – Aviello, Roano, Borrelli, Capasso, Gallo, Piscitelli, Di Marzo & Izzo (2012) – Journal of Molecular Medicine |
| Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1 – Ramer, Bublitz, Freimuth, Merkord, Rohde, Haustein, Borchert, Schmuhl, Linnebacher & Hinz (2012) – FASEB Jorunal |
| Cannabidiol inhibits angiogenesis by multiple mechanisms – Solinas Massi, Cantelmo, Cattaneo, Cammarota, Bartolini, Cinquina, Valenti, Vicentini,Noonan, Albini & Parolaro (2012) – British Journal of Pharmacology |
| Update on the endocannabinoid system as an anticancer target – Malfitano, Ciaglia, Gangemi & Bifulco (2011) – Expert Opinion on Theraputic Targets |
| Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion – Nasser, Qamri, Deol, Smith, Shilo, Zou & Ganju (2011) – PLOS One |
| Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis. – Preet, Qamri, Nasser, Prasad, Shilo, Zou, Groopman & Ganju (2011) – Cancer Prevention Research |
| Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy – Vara, Salazar, Olea-Herrero, Guzman, Velasco & Diaz-Laviada (2011) – Cell Death and Differentiation |
| Plasma cannabinoid pharmacokinetics following controlled oral delta9-tetrahydrocannabinol and oromucosal cannabis extract administration – Karschner, Darwin, Goodwin, Wright & Huestis (2011) – Clinical Chemistry |
| Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis – McAllister, Murase, Christian, Lau, Zielinski, Allison, Almanza, Pakdel, Lee, Limbard, Liu, Debs, Moore & Desprez (2011) – Breast Cancer Research and Treatment |
| Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy – Shrivastava, Kuzontkoski, Groopman & Prasad (2011) – Molecular Cancer Theraputics |
| A combined preclinical therapy of cannabinoids and temozolomide against glioma – Torres, Lorente, Rodrigues-Formes, Hemandez-Tiedra, Salazar, Garcia-Taboada, Barcia, Guzman & Valasco (2011) – Molecular Cancer Theraputics |
| Cannabis-derived substances in cancer therapy–an emerging anti-inflammatory role for the cannabinoids. – Liu, Fowler & Dalgleish (2010) – Current Clinical Pharmacology |
| Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition – Caffarel, Andradas, Mira, Perez-Gomez, Cerutti, Moreno-Bueno, Flores, Garcia-Real, Palacios, Manes, Guzman & Sanchez (2010) – Lmolecular Cancer |
| Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells – Ramer, Rohde, Merkord, Rohde & Hinz (2010) – Parmaceutical Research |
| Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1 – Ramer, Merkord, Rohde & Hinz (2010) – Biochemical Pharmacology |
| Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival – Marcu, Christian, Lau, Zielinski, Horowitz, Lee, Pakdel, Allison, Limbad, Moore, Yount, Desperez & McAllister (2010) – Molecular Cancer Theraputics |
| Antitumorigenic effects of cannabinoids beyond apoptosis – Freimuth, Ramer & Hinz (2010) – Journal of Pharmacology and Experimental Theraputics |
| Analysis of natural product regulation of cannabinoid receptors in the treatment of human disease – Badal, Smith & Rajnarayanan (2009) – Pharmacology & Theraputics |
| Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer – Qamri, Preet, Nasser, Bass, Leone, Barsky & Ganju (2009) – Molecular Cancer Theraputics |
| Cannabinoids and cancer: pros and cons of an antitumour strategy – Bifulco, Laezza, Pisanti & Gazzerro (2009) – British Journal of Pharmacology |
| Cannabinoids for cancer treatment: progress and promise – Sarfaraz, Adhami, Syed, Afaq & Mukhtar (2008) – Cancer Research |
| Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo – Preet, Ganju & Groopman (2008) – Oncogene |
| Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1 – Ramer & Hinz (2008) – Journal of the National Cancer Institute |
| Endocannabinoids in endocrine and related tumours – Bifulco, Malfitano, Pisanti & Laezza (2008) – Endocrine-Related Cancer |
| Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de nono synthesis in colon cancer cells – Cianchi, Papucci, Schiavone, Lulli, Magnelli, Vinci, Messerini,Manera, Ronconi, Romagnani, Donnini, Perigli, Trallori, Tangabelli, Capaccioli & Masini (2008) – Clinical Cancer Research |
| Cannabidiol-induced apoptosis in primary lymphocytes is associated with oxidative stress-dependent activation of caspase-8. Toxicol Appl Pharmacol – Wu, Chu, Wang, Lee, Lin, & Jan (2008) – Toxicology and Applied Pharmacology |
| A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells – Lee, Wey, Liao & Jan (2008) – International Immunopharmacology |
| 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid – Massi, Valenti, Vaccani, Gasperi, Perletti, Marras, Fezza, Maccarrone, Parolaro (2008) – Journal of Neurochmistry |
| Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells – McAllister, Christian, Horowitz, Garcia & Desprez (2007) – Molecular Cancer Theraputics |
| The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells – Massi, Vaccani, Bianchessi, Costa, Macchi & Parolaro (2006) – Cellular and Molecular Life Sciences |
| Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes – Carracedo, Gironella, Lorente, Garcia, Guzman, Velasco & Iovanna (2006) – Cancer Research |
| Cannabinoid receptors as novel targets for the treatment of melanoma – Blázquez, Carracedo, Barrado, Real, Fernandez-Luna, Valesco, Malumbres & Guzman (2006) – FASEB Jorunal |
| Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression – McKallip, Jia, Schlomer, Warren, Nagarkatti & Nagarkatti (2006) – Molecular Pharmacology |
| Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma – Ligresti, Moriello, Starowicz, Matias, Pisanti, De Petrocellis, Laezza, Portella, Bifulco & Di Marzo (2006) – Journal of Pharmacology and Experimental Theraputics |
| Cannabinoids and cancer: potential for colorectal cancer therapy – Patsos, Hicks, Greenhought, Williams & Paraskeva (2005) – Biochemical Society Transactions |
| Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism – Vaccani, Massi, Colombo, Rubino & Parolaro (2005) – Biochemical Pharmacology |
| Tetrahydrocannabinol Enhances Breast Cancer Growth and Metastasis by Suppression of the Antitumor Immune Response – McKallip, Nagarkatti & Nagarkatti (2005) – The Journal of Immunology |
| The endogenous cannabinoid system protects against colonic inflammation – Massa, Marsicano, Hermann, Cannich, Monory, Cravatt, Ferri, Sibaev, Storr & Lutz (2004) – The Journal of Clinical Investigation |
| Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas – Blazquez, Gonzalez-Feria, Alvarez et al (2004) – Cancer Research |
| Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines – Massi, Vaccani, Ceruti, Colombo, Abbacchio & Parolaro (2004) – Journal of Pharmacology and Experimental Theraputics |
| Inhibition of tumor angiogenesis by cannabinoids – Blazquez, Casanova, Planas, Pulgar, Vilanueva, Fernandez-Acenero, Aragones, Huffman, Jorcano & Guzman (2003) – The FASEB Journal |
| Cannabinoids: potential anticancer agents – Guzman (2003) – Nature Review Cancer |
| Inhibition of skin tumour growth and angiogenesis in vivo by activation of cannabinoid receptors – Casanova, Blazquez, Martinez-Palacio, Villanueva, Fernandez-Acenero, Huffman, Jorcano & Guzman (2003) – The Journal of Clinical Investigation |
| Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells. Leuk Lymphoma – Gallily, Even-Chena, Katzavian, Lehmann, Dagan & Mechoulam (2003) – Leukemia & Lymphoma |
| Targeting the endocannabinoid system in cancer therapy: a call for further research – Bifulco & di Marzo (2002) – Nature Medicine |
| Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease – McKallip, Lombard, Fisher, Martin, Ryu, Grant, Nagarkatti & Nagarkatti (2002) – Blood |
| Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor – Sánchez, Ceballos, Pulgar, Rueda, Corbacho, Velasco, Galve-Roperh, Huffman, Ramon y Cajal & Guzman (2001) – Cancer Research |
| Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation – Galye-Roperh, Sanchez, Cortes, Pulgar, Izquierdo & Guzman (2000) – Nature America |
| Tetrahydrocannabinol Treatment Suppresses Immunity and Early IFN-γ, IL-12, and IL-12 Receptor β2 Responses to Legionella pneumophila Infection – Klein, Newton, Nakachi & Friedman (2000) – The Journal of Immunology |
| Tetrahydrocannabinol Inhibits Antitumor Immunity by a CB2 Receptor-Mediated, Cytokine-Dependent Pathway – Zhu, Sharma, Stolina, Gardner, Roth, Tashkin & Dubinett (2000) – The Journal of Immunology |
| NTP Toxicology and Carcinogenesis Studies of 1-Trans-Delta(9)-Tetrahydrocannabinol (CAS No. 1972-08-3) in F344 Rats and B6C3F1 Mice – National Toxicity Programme (1996) – |
| Assay of plasma cannabidiol by capillary gas chromatography/ion trap mass spectroscopy following high-dose repeated daily oral administration in humans – Consroe, Kennedy & Schram (1991) – Pharmacology, Biochemistry & Behaviour |
| Antineoplastic activity of cannabinoids – Munson, Harris, Friedman, Dewey & Carchman (1975) – Journal of the National Cancer Institute |
Diet
| Dietary Fat and Sugar in Promoting Cancer Development and Progression – Goncalves, Hopkins & Cantley (2019) – Annual Review of Cancer Biology |
| Improving the Quality of Dietary Research – Ludwig, Ebbeling & Heymsfield (2019) – JAMA |
| Ketogenic diet combined with antioxidant N-acetylcysteine inhibits tumor growth in a mouse model of anaplastic thyroid cancer – Aggarwal, Yuan, Barletta, Lorch & Nehs (2019) – Presented at the American Association of Endocrine Surgeons |
| Ketogenic diet in the treatment of cancer – Where do we stand? – Weber, Aminzadeh-Gohari, Tulipan, Catalano, Feichtinger & Kofler (2019) – Molecular Metabolism |
| Ketogenic diet treatment in recurrent diffuse intrinsic pontine glioma in children: A safety and feasibility study – Van der Louw, Reddingius, Olieman, Neuteboom & Catsman-Berrevoets (2019) – Paediatric Blood Cancer |
| The ERK and JNK pathways in the regulation of metabolic reprogramming – Papa, Choy & Bubici (2019) – Oncogene |
| Adherence to low carbohydrate diet in relation to glioma: A case-control study – Ebrahimpour-Koujan, Shayanfar, Benisi-Kohansal, Mohammad-Shirazi, Sharifi & Esmaillzadeh (2018) – Clinical Nutrition |
| Effects of Ketogenic Diet for Breast Cancer Treatment. A Protocol for Randomized Controlled Clinical Trial – Khodabakhshi, Akbari, Mirzaei, Kazemian, Kalantari, Kalamian, Sotoudeh & Davoodi (2018) – Journal of Biochemical Technology |
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